Synthesis, antifungal activity and in silico ADMET studies of benzyl alcohol derivatives

Synthesis, Structure-Activity Relationships (SAR) and in Silico Studies of Coumarin Derivatives with Antifungal Activity

The increased incidence of opportunistic fungal infections, associated with greater resistance to the antifungal drugs currently in use has highlighted the need for new solutions. In this study twenty four coumarin derivatives were screened in vitro for antifungal activity against strains of Aspergillus. Some of the compounds exhibited significant antifungal activity with MICs values ranging be...

Synthesis and antifungal activity of carabrone derivatives.

Nine derivatives 6-14 of carabrone (1) were synthesized and tested in vitro against Colletotrichum lagenarium Ell et Halst using the spore germination method. Among all of the derivatives, compounds 6-8 and 12 showed more potent antifungal activity than 1. Structure-activity relationships (SAR) demonstrated that the γ-lactone was necessary for the antifungal activity of 1, and the substituents ...

Oleoylsalicylate Derivatives: Synthesis and Antifungal Activity

Three new “hybrid” molecules containing the skeleton of oleic acid and salicylic acid were synthesised. A qualitative study of the chemical stability of two of them and a preliminary evaluation of their biological activity in vivo and in vitro were performed against a series of important plant pathogens.

comparison of catalytic activity of heteropoly compounds in the synthesis of bis(indolyl)alkanes.

heteropoly acids (hpa) and their salts have advantages as catalysts which make them both economically and environmentally attractive, strong br?nsted acidity, exhibiting fast reversible multi-electron redox transformations under rather mild conditions, very high solubility in polar solvents, fairly high thermal stability in the solid states, and efficient oxidizing ability, so that they are imp...

synthesis and antifungal activity of benzimidazole, benzotriazole and aminothiazole derivatives